Clinical effect of point mutations in myelodysplastic syndromes Academic Article uri icon

Overview

MeSH Major

  • Myelodysplastic Syndromes
  • Point Mutation

abstract

  • Somatic point mutations are common in myelodysplastic syndromes and are associated with specific clinical features. Mutations in TP53, EZH2, ETV6, RUNX1, and ASXL1 are predictors of poor overall survival in patients with myelodysplastic syndromes, independently of established risk factors. (Funded by the National Institutes of Health and others.).

publication date

  • June 30, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3159042

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1013343

PubMed ID

  • 21714648

Additional Document Info

start page

  • 2496

end page

  • 506

volume

  • 364

number

  • 26