Mayo genome consortia: A genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels Academic Article uri icon

Overview

MeSH Major

  • Bilirubin
  • Genome-Wide Association Study
  • Glucuronosyltransferase
  • Organic Anion Transporters
  • Polymorphism, Genetic

abstract

  • Genome-wide association studies have identified genetic variants associated with numerous phenotypes but have been historically limited by inadequate sample size due to costly genotyping and phenotyping. Large consortia with harmonized genotype data have been assembled to attain sufficient statistical power, but phenotyping remains a rate-limiting factor in gene discovery research efforts. The EMR consists of an abundance of phenotype data that can be extracted in a relatively quick and systematic manner. The MayoGC provides a model of a unique collaborative effort in the environment of a common EMR for the investigation of genetic determinants of diseases.

publication date

  • January 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3127556

Digital Object Identifier (DOI)

  • 10.4065/mcp.2011.0178

PubMed ID

  • 21646302

Additional Document Info

start page

  • 606

end page

  • 14

volume

  • 86

number

  • 7