Synaptic vesicle retrieval time is a cell-wide rather than individual-synapse property Academic Article uri icon

Overview

MeSH Major

  • Neurons
  • Presynaptic Terminals
  • Synapses
  • Synaptic Vesicles

abstract

  • Although individual nerve terminals from the same neuron often differ in neurotransmitter release characteristics, the extent to which endocytic retrieval of synaptic vesicle components differs is unknown. We used high-fidelity optical recordings to undertake a large-scale analysis of endocytosis kinetics of individual boutons in hippocampal rat neurons. Our data indicate that endocytosis kinetics do not differ substantially across boutons from the same cell but instead appear to be controlled at a cell-wide level.

publication date

  • July 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3125437

Digital Object Identifier (DOI)

  • 10.1038/nn.2828

PubMed ID

  • 21623361

Additional Document Info

start page

  • 824

end page

  • 6

volume

  • 14

number

  • 7