Circulating tumor cells as biomarkers in prostate cancer Review uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Neoplastic Cells, Circulating
  • Prostatic Neoplasms

abstract

  • Unmet needs in prostate cancer drug development and patient management are the ability to monitor treatment effects and to identify therapeutic targets in a tumor at the time treatment is being considered. This review focuses on establishing analytically valid biomarkers for specific contexts of use in patients with castration-resistant prostate cancer (CRPC), emphasizing a biomarker currently in clinical use, circulating tumor cells (CTC). The FDA Critical Path provides a road map for these investigations, which, if followed, will facilitate the incorporation of these types of assays into clinical decision-making. CTC enumeration at baseline and post-treatment is prognostic of survival, with no threshold effect, and the shedding of cells into the circulation represents an intrinsic property of the tumor, distinct from extent of disease. The clinical utility of monitoring CTC changes with treatment, as an efficacy-response surrogate biomarker of survival, is currently being tested in large phase III trials, with the novel antiandrogen therapies abiraterone acetate and MDV3100. Molecular determinants can be identified and characterized in CTCs as potential predictive biomarkers of tumor sensitivity to a therapeutic modality. Additionally, we discuss novel technologies to enrich and characterize CTCs from more patients, the potential clinical uses of CTCs in determining prognosis and monitoring treatment effects, and CTCs as a source of tissue to identify predictive markers of drug sensitivity to guide treatment selection. Prospective studies, designed around the biomarker itself and the specific clinical context for which it is applied, are needed to further assess the role of these and novel markers in clinical practice.

publication date

  • June 15, 2011

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3743247

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-10-2650

PubMed ID

  • 21680546

Additional Document Info

start page

  • 3903

end page

  • 12

volume

  • 17

number

  • 12