Treatment-related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in myeloproliferative neoplasms Academic Article uri icon

Overview

MeSH Major

  • Leukemia, Myeloid, Acute
  • Myelodysplastic Syndromes
  • Polycythemia Vera
  • Primary Myelofibrosis
  • Thrombocythemia, Essential

abstract

  • The risk of AML/MDS development after MPN diagnosis was significantly associated with high exposures of P(32) and alkylators but not with HU treatment. Twenty-five percent of patients with MPNs who developed AML/MDS were not exposed to cytotoxic therapy, supporting a major role for nontreatment-related factors.

publication date

  • June 10, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3107755

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.34.7542

PubMed ID

  • 21537037

Additional Document Info

start page

  • 2410

end page

  • 5

volume

  • 29

number

  • 17