Mitochondrial ceramide-rich macrodomains functionalize bax upon irradiation Academic Article uri icon

Overview

MeSH Major

  • Ceramides
  • Mitochondria
  • bcl-2-Associated X Protein

abstract

  • Our recent studies in the C. elegans germline indicate that mitochondrial ceramide generation is obligate for radiation-induced apoptosis, although a mechanism for ceramide action was not delineated. Here we demonstrate that ceramide, generated in the mitochondrial outer membrane of mammalian cells upon irradiation, forms a platform into which Bax inserts, oligomerizes and functionalizes as a pore. We posit conceptualization of ceramide as a membrane-based stress calibrator, driving membrane macrodomain organization, which in mitochondria regulates intensity of Bax-induced MOMP, and is pharmacologically tractable in vitro and in vivo.

publication date

  • June 16, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3113798

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0019783

PubMed ID

  • 21695182

Additional Document Info

start page

  • e19783

volume

  • 6

number

  • 6