Pharmacokinetics of polymyxin B in an infant with multidrug-resistant klebsiella pneumoniae bacteremia Academic Article uri icon

Overview

MeSH Major

  • Anti-Bacterial Agents
  • Bacteremia
  • Drug Resistance, Multiple, Bacterial
  • Klebsiella Infections
  • Klebsiella pneumoniae
  • Polymyxin B

abstract

  • We report our experience with a 9-month-old infant treated with intravenous polymyxin B for multidrug-resistant Klebsiella pneumoniae bacteremia. Serial blood samples were obtained at steady state and serum drug concentrations were determined using a validated liquid chromatography-mass spectrometry method. The elimination half-lives of polymyxin B1 and isoleucine-polymyxin B1 were found to be 3.1 and 4.7 hours, respectively.

publication date

  • June 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/INF.0b013e318207a7c1

PubMed ID

  • 21164382

Additional Document Info

start page

  • 537

end page

  • 9

volume

  • 30

number

  • 6