Incidence of EGFR Exon 19 deletions and 1858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas Academic Article uri icon

Overview

MeSH Major

  • Receptor, Epidermal Growth Factor
  • Sequence Deletion
  • Smoking

abstract

  • A large number of EGFR mutations are found in adenocarcinoma tumor specimens from men and people who smoked cigarettes. If only women who were never smokers were tested, 57% of all EGFR mutations would be missed. Testing for EGFR mutations should be considered for all patients with adenocarcinoma of the lung at diagnosis, regardless of clinical characteristics. This strategy can extend the use of EGFR tyrosine kinase inhibitors to the greatest number individuals with the potential for substantial benefit.

publication date

  • May 20, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3296671

Digital Object Identifier (DOI)

  • 10.1200/JCO.2010.32.6181

PubMed ID

  • 21482987

Additional Document Info

start page

  • 2066

end page

  • 70

volume

  • 29

number

  • 15