Changes in lipid profiles in morbidly obese patients after laparoscopic sleeve gastrectomy (LSG). Academic Article uri icon

Overview

MeSH

  • Adolescent
  • Adult
  • Aged
  • Body Mass Index
  • Female
  • Humans
  • Laparoscopy
  • Lipoproteins, HDL
  • Male
  • Middle Aged
  • Postoperative Period
  • Triglycerides
  • Young Adult

MeSH Major

  • Gastrectomy
  • Lipids
  • Obesity, Morbid

abstract

  • Laparoscopic sleeve gastrectomy (LSG) has evolved as a primary weight loss surgery. This study provides changes in lipid profiles in obese patients 1 year after LSG. A retrospective analysis of patients who underwent LSG from June 2004 to June 2008 provided data on demographics, body mass index (BMI) changes, co-morbidities, and medication changes. We compared lipid profiles, and the relationship between the lipid profiles and pre-operative weight, BMI, and weight loss. Proportion changes for all variables were also assessed. Lipid profiles for those taking lipid-lowering therapy and patients receiving no medication were evaluated. Data is presented on 45 patients (58% women) ages 18 to 73 years. Co-morbidities included hypertension (19), hyperlipidemia (22), and diabetes (13). One year after LSG, weight decreased from 161.4 ± 34.3 to 112.9 ± 25.6 kg (p < 0.01). BMI decreased from 57.5 ± 9.6 to 39.9 ± 7.1 kg/m(2) (p < 0.01). Patients with elevated triglycerides decreased from 17 to 8 (p < 0.01) while patients with elevated cholesterol increased from 13 to 15. High-density lipoprotein cholesterol (HDL) increased from 48.4 to 54.5 mg/dl (p < 0.01) and triglycerides (TG) decreased from 141.7 to 109.3 mg/dl (p < 0.01). TC/HDL and TG/HDL ratios also, decreased significantly (p < 0.01). There were no changes for total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). TG/HDL changes correlated with pre-op weight (r = 0.363, p < 0.05). One year after LSG, significant weight loss and improvements in HDL and TG levels, TC/HDL and TG/HDL ratios were observed. TC and LDL levels were unchanged.

publication date

  • March 2011

has subject area

  • Adolescent
  • Adult
  • Aged
  • Body Mass Index
  • Female
  • Gastrectomy
  • Humans
  • Laparoscopy
  • Lipids
  • Lipoproteins, HDL
  • Male
  • Middle Aged
  • Obesity, Morbid
  • Postoperative Period
  • Triglycerides
  • Young Adult

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s11695-010-0285-x

PubMed ID

  • 20859769

Additional Document Info

start page

  • 305

end page

  • 309

volume

  • 21

number

  • 3