Ligands for copper-catalyzed C-N bond forming reactions with 1 Mol% CuBr as catalyst Academic Article uri icon

Overview

MeSH Major

  • Bromides
  • Carbon
  • Copper
  • Nitrogen

abstract

  • Several new ligands were designed to promote copper-catalyzed Ullman C-N coupling reactions. In this group, 8-hydroxyquinolin-N-oxide was found to serve as a superior ligand for CuBr-catalyzed coupling reactions of aryl iodides, bromides, and chlorides with aliphatic amines and N-heterocycles under a low catalyst loading (1% [Cu] mol). Reactions with the inexpensive catalytic system display a high functional group tolerance as well as excellent chemoselectivity.

publication date

  • May 6, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1021/jo1026035

PubMed ID

  • 21425835

Additional Document Info

start page

  • 3151

end page

  • 9

volume

  • 76

number

  • 9