A user's guide to the Encyclopedia of DNA elements (ENCODE) Academic Article uri icon

Overview

MeSH Major

  • Databases, Nucleic Acid
  • Genome, Human

abstract

  • The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.

authors

publication date

  • April 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3079585

Digital Object Identifier (DOI)

  • 10.1371/journal.pbio.1001046

PubMed ID

  • 21526222

Additional Document Info

start page

  • e1001046

volume

  • 9

number

  • 4