Integrated profiling of diffuse large B-cell lymphoma with 7q gain Academic Article uri icon

Overview

MeSH Major

  • Chromosome Duplication
  • Chromosomes, Human, Pair 7
  • Lymphoma, Large B-Cell, Diffuse

abstract

  • To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

publication date

  • May 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2141.2011.08628.x

PubMed ID

  • 21418177

Additional Document Info

start page

  • 499

end page

  • 503

volume

  • 153

number

  • 4