Down-regulation of the canonical wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD Academic Article uri icon

Overview

MeSH Major

  • Pulmonary Disease, Chronic Obstructive
  • Smoking
  • Wnt Proteins
  • beta Catenin

abstract

  • Smoking down-regulates the Wnt pathway in the human airway epithelium. In the context that Wnt pathway plays an important role in differentiation of epithelial tissues, the down-regulation of Wnt pathway may contribute to the dysregulation of airway epithelium differentiation observed in smoking-related airway disorders.

publication date

  • April 20, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3072378

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0014793

PubMed ID

  • 21490961

Additional Document Info

start page

  • e14793

volume

  • 6

number

  • 4