AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization Academic Article uri icon

Overview

MeSH Major

  • AMP-Activated Protein Kinases
  • Axons
  • Cell Polarity
  • Neurons
  • Phosphatidylinositol 3-Kinase

abstract

  • Axon-dendrite polarization is crucial for neural network wiring and information processing in the brain. Polarization begins with the transformation of a single neurite into an axon and its subsequent rapid extension, which requires coordination of cellular energy status to allow for transport of building materials to support axon growth. We found that activation of the energy-sensing adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway suppressed axon initiation and neuronal polarization. Phosphorylation of the kinesin light chain of the Kif5 motor protein by AMPK disrupted the association of the motor with phosphatidylinositol 3-kinase (PI3K), preventing PI3K targeting to the axonal tip and inhibiting polarization and axon growth.

publication date

  • April 8, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3325765

Digital Object Identifier (DOI)

  • 10.1126/science.1201678

PubMed ID

  • 21436401

Additional Document Info

start page

  • 247

end page

  • 51

volume

  • 332

number

  • 6026