Morphea as a consequence of accelerated partial breast irradiation Academic Article uri icon


MeSH Major

  • Brachytherapy
  • Breast Neoplasms
  • Carcinoma, Ductal, Breast
  • Radiation Injuries
  • Scleroderma, Localized


  • Morphea is a localized form of scleroderma usually unaccompanied by the typical systemic stigmata that characterize progressive systemic scleroderma. It rarely manifests at the site of whole breast external-beam radiation therapy. We present an unusual case of radiation-induced morphea (RIM) that occurred after accelerated partial breast irradiation (APBI) using intracavitary Contura brachytherapy. A 65-year-old white woman was treated for stage IIA invasive ductal carcinoma of the left breast with APBI to a dose of 34 Gy in 3.4-Gy fractions twice daily over the course 5 days with intracavitary brachytherapy. At 1.5 years after completion of APBI, the patient developed an area of tenderness, erythema, and induration at the site of irradiation. A skin biopsy was consistent with morphea. To our knowledge, this is the first case of RIM confined to the area of APBI.

publication date

  • March 2011



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.3816/CBC.2011.n.012

PubMed ID

  • 21421525

Additional Document Info

start page

  • 67

end page

  • 70


  • 11


  • 1