Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat Academic Article uri icon

Overview

MeSH Major

  • Adipose Tissue
  • Inflammation
  • Macrophage Activation
  • Macrophages
  • Mesenteric Arteries
  • Vasoconstriction

abstract

  • The presence and activation of macrophages in adipose tissue is the key modulator of the increase in contractility in arteries with perivascular fat following induction of inflammation. Despite multiple factors that may be involved in bringing about the vascular consequences of obesity, the ability of eplerenone to ameliorate the inflammatory effects of both aldosterone and hypoxia may be of potential therapeutic interest.

publication date

  • April 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.110.221705

PubMed ID

  • 21273560

Additional Document Info

start page

  • 908

end page

  • 13

volume

  • 31

number

  • 4