'Non-criteria' aPL tests: Report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April 2010 Conference Paper uri icon

Overview

MeSH Major

  • Blood Platelets
  • Cycloheptanes
  • Hydroxyquinolines
  • Indium
  • Organometallic Compounds
  • Oxyquinoline
  • Radioisotopes
  • Tropolone

abstract

  • Current classification criteria for definite APS recommend the use of one or more of three positive standardized laboratory assays, including anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and antibodies directed to β2glycoprotein I (anti-β2GPI) to detect antiphospholipid antibodies (aPL) in the presence of at least one of the two major clinical manifestations (i.e., thrombosis or pregnancy morbidity) of the syndrome. Several other autoantibodies shown to be directed to phospholipids and/or their complexes with phospholipids and/or to proteins of the coagulation cascade, as well as a mechanistic test for resistance to annexin A5 anticoagulant activity, have been proposed to be relevant to APS. A task force of worldwide scientists in the field discussed and analyzed critical questions related to 'non-criteria' aPL tests in an evidence-based manner during the 13th International Congress on Antiphospholipid Antibodies (APLA 2010, 13-16 April 2010, Galveston, Texas, USA). This report summarizes the findings, conclusions, and recommendations of this task force. © The Author(s), 2011.

publication date

  • January 2011

Research

keywords

  • Conference Paper

Identity

Digital Object Identifier (DOI)

  • 10.1177/0961203310397082

Additional Document Info

start page

  • 191

end page

  • 205

volume

  • 20

number

  • 2