Selected human leukocyte antigen class II polymorphisms and risk of adult glioma Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Genetic Predisposition to Disease
  • Glioma
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • Polymorphism, Genetic

abstract

  • Few studies have examined the relationship between human leukocyte antigen (HLA) polymorphisms and adult glioma, particularly at class II loci. We evaluated the association between selected HLA class II polymorphisms and adult glioma in a large, hospital-based case-control study, using unconditional logistic regression. DQB1 06 (OR=1.67, 95% CI=1.17-2.39) and DRB1 13 (OR=1.69, 95% CI=1.08-2.64) alleles were associated with an increased risk of glioma, while the DQB1 05 allele showed an inverse association (OR=0.63, 95% CI=0.43-0.93). These results, which were of borderline significance once controlled for the false discovery rate, suggest a potential role for the DQB1 06, DQB1 05, and DRB1 13 alleles in glioma susceptibility.

publication date

  • April 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3074044

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2010.11.005

PubMed ID

  • 21195488

Additional Document Info

start page

  • 185

end page

  • 91

volume

  • 233

number

  • 1-2