Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis Academic Article uri icon

Overview

MeSH Major

  • Cartilage, Articular
  • Chondrocytes
  • Osteoarthritis
  • Suppressor of Cytokine Signaling Proteins

abstract

  • This study demonstrates the reduced expression of SOCS2 and CIS-1 in OA, while SOCS1 and SOCS3 were unaffected. The observation that long-term treatment with inflammatory cytokines attenuated the expression of SOCS2 and CIS-1 suggests a potential positive feedback mechanism, and a role of SOCS in the pathology of OA.

publication date

  • April 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3937865

Digital Object Identifier (DOI)

  • 10.1016/j.bbrc.2011.02.101

PubMed ID

  • 21352802

Additional Document Info

start page

  • 54

end page

  • 9

volume

  • 407

number

  • 1