Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques Academic Article uri icon

Overview

MeSH Major

  • Disease Models, Animal
  • Genes, Switch
  • Hypercholesterolemia
  • Macrophages
  • Plaque, Atherosclerotic

abstract

  • The Reversa mouse is a new model of atherosclerosis regression. After lipid lowering, favorable changes in plaque composition were independent of changes in size. In addition, plaque CD68(+) cells became less inflammatory, an effect enhanced by treatment with pioglitazone.

publication date

  • March 8, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3131163

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.110.984146

PubMed ID

  • 21339485

Additional Document Info

start page

  • 989

end page

  • 98

volume

  • 123

number

  • 9