Down-regulation of microRNA 106b is involved in p21-mediated cell cycle arrest in response to radiation in prostate cancer cells Academic Article uri icon

Overview

MeSH Major

  • Cell Cycle
  • Gene Expression Regulation, Neoplastic
  • MicroRNAs
  • Prostatic Neoplasms
  • p21-Activated Kinases

abstract

  • We have shown a novel role of miR-106b, in the setting of radiation treatment, in regulating the p21-activated cell cycle arrest. Our finding that miR-106b is able to override radiation-induced cell cycle arrest and cell growth inhibition points to a potential therapeutic target in certain prostate cancer cells whose radiation resistance is likely due to consistently elevated level of miR-106b.

publication date

  • May 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/pros.21272

PubMed ID

  • 20878953

Additional Document Info

start page

  • 567

end page

  • 74

volume

  • 71

number

  • 6