Bivalirudin utilization in cardiac surgery: Shifting anticoagulation from indirect to direct thrombin inhibition Review uri icon

Overview

MeSH Major

  • Antithrombins
  • Cardiac Surgical Procedures
  • Peptide Fragments

abstract

  • Although bivalirudin is not approved for cardiac surgery in the United States, it can be used in this setting in Canada as an anticoagulant in patients with heparin-induced thrombocytopenia provided the cardiac anesthesiologist is knowledgeable about potential complications from its use and knows how to manage or mitigate their incidence appropriately. During cardiopulmonary bypass, bivalirudin anticoagulation protocols must be thoroughly followed to attain optimal clinical outcomes. Additionally, further studies with bivalirudin are needed to determine the best monitoring modality and dosing regimen.

publication date

  • March 2011

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s12630-010-9423-0

PubMed ID

  • 21136312

Additional Document Info

start page

  • 296

end page

  • 311

volume

  • 58

number

  • 3