Imaging colon cancer response following treatment with AZD1152: A preclinical analysis of [18F]fluoro-2-deoxyglucose and 3′-deoxy-3′-[18F]fluorothymidine imaging Academic Article uri icon

Overview

MeSH Major

  • Colonic Neoplasms
  • Dideoxynucleosides
  • Fluorodeoxyglucose F18
  • Organophosphates
  • Positron-Emission Tomography
  • Quinazolines

abstract

  • AZD1152 treatment showed antitumor efficacy in both colon cancer xenografts. Although [(18)F]FDG PET was inadequate in monitoring treatment response, [(18)F]FLT PET was very effective in monitoring response in HCT116 xenografts, but not in SW620 xenografts. These observations suggest that de novo thymidine synthesis could be a limitation and confounding factor for [(18)F]FLT PET imaging and quantification of tumor proliferation, and this may apply to some clinical studies as well.

publication date

  • March 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3079195

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-10-1430

PubMed ID

  • 21245090

Additional Document Info

start page

  • 1099

end page

  • 110

volume

  • 17

number

  • 5