Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay Academic Article uri icon

Overview

MeSH Major

  • Drug Resistance, Neoplasm
  • Lung Neoplasms
  • Mutation
  • Polymerase Chain Reaction
  • Receptor, Epidermal Growth Factor

abstract

  • The re-biopsy of lung cancer patients with acquired resistance is feasible and provides sufficient material for mutation analysis in most patients. Using high sensitivity methods, the T790M is detected in up to 68% of these patients.

publication date

  • March 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3070951

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-10-2277

PubMed ID

  • 21248300

Additional Document Info

start page

  • 1169

end page

  • 80

volume

  • 17

number

  • 5