Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: A meta-analysis of randomized clinical trials Review uri icon

Overview

MeSH Major

  • Diuretics, Osmotic
  • Intracranial Hypertension
  • Mannitol
  • Saline Solution, Hypertonic

abstract

  • We found that hypertonic saline is more effective than mannitol for the treatment of elevated intracranial pressure. Our meta-analysis is limited by the small number and size of eligible trials, but our findings suggest that hypertonic saline may be superior to the current standard of care and argue for a large, multicenter, randomized trial to definitively establish the first-line medical therapy for intracranial hypertension.

publication date

  • March 2011

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/CCM.0b013e318206b9be

PubMed ID

  • 21242790

Additional Document Info

start page

  • 554

end page

  • 9

volume

  • 39

number

  • 3