Common variants in ZNF365 are associated with both mammographic density and breast cancer risk Review uri icon

Overview

MeSH Major

  • Breast
  • Breast Neoplasms
  • DNA-Binding Proteins
  • Genetic Variation
  • Transcription Factors

abstract

  • High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.

authors

publication date

  • March 2011

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3076615

Digital Object Identifier (DOI)

  • 10.1038/ng.760

PubMed ID

  • 21278746

Additional Document Info

start page

  • 185

end page

  • 7

volume

  • 43

number

  • 3