Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Academic Article uri icon

Overview

MeSH

  • Adult
  • Brain Mapping
  • Choice Behavior
  • Communication
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Oxygen
  • Young Adult

MeSH Major

  • Brain
  • Brain Injuries
  • Cognition Disorders
  • Magnetic Resonance Imaging

abstract

  • Functional neuroimaging methods hold promise for the identification of cognitive function and communication capacity in some severely brain-injured patients who may not retain sufficient motor function to demonstrate their abilities. We studied seven severely brain-injured patients and a control group of 14 subjects using a novel hierarchical functional magnetic resonance imaging assessment utilizing mental imagery responses. Whereas the control group showed consistent and accurate (for communication) blood-oxygen-level-dependent responses without exception, the brain-injured subjects showed a wide variation in the correlation of blood-oxygen-level-dependent responses and overt behavioural responses. Specifically, the brain-injured subjects dissociated bedside and functional magnetic resonance imaging-based command following and communication capabilities. These observations reveal significant challenges in developing validated functional magnetic resonance imaging-based methods for clinical use and raise interesting questions about underlying brain function assayed using these methods in brain-injured subjects.

publication date

  • March 2011

has subject area

  • Adult
  • Brain
  • Brain Injuries
  • Brain Mapping
  • Choice Behavior
  • Cognition Disorders
  • Communication
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Oxygen
  • Young Adult

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3044833

Digital Object Identifier (DOI)

  • 10.1093/brain/awr005

PubMed ID

  • 21354974

Additional Document Info

start page

  • 769

end page

  • 782

volume

  • 134

number

  • Pt 3