TP53 and MTOR crosstalk to regulate cellular senescence. Editorial Article uri icon

Overview

MeSH Major

  • Cell Aging
  • TOR Serine-Threonine Kinases
  • Tumor Suppressor Protein p53

abstract

  • The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53.

publication date

  • September 2010

Research

keywords

  • Editorial

Identity

Language

  • eng

PubMed Central ID

  • PMC2984599

PubMed ID

  • 20876940

Additional Document Info

start page

  • 535

end page

  • 7

volume

  • 2

number

  • 9