High-Yielding, Two-Step 18F Labeling Strategy for 18F-PARP1 Inhibitors
Poly(ADP-ribose) Polymerase Inhibitors
Speedy and easy! An 18F-labeled PARP1 imaging agent, based on AZD2281, was prepared via an inverse electron demand Diels-Alder cycloaddition in high radiochemical yield for positron emission tomography (PET) imaging. This strain-promoted 'bioorthogonal' reaction is envisioned to be a widely applicable 18F-labeling strategy for repeat and on-demand synthesis of small molecules for PET imaging. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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