High-Yielding, Two-Step 18F Labeling Strategy for 18F-PARP1 Inhibitors Academic Article uri icon

Overview

MeSH Major

  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors

abstract

  • Speedy and easy! An 18F-labeled PARP1 imaging agent, based on AZD2281, was prepared via an inverse electron demand Diels-Alder cycloaddition in high radiochemical yield for positron emission tomography (PET) imaging. This strain-promoted 'bioorthogonal' reaction is envisioned to be a widely applicable 18F-labeling strategy for repeat and on-demand synthesis of small molecules for PET imaging. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

publication date

  • March 7, 2011

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/cmdc.201000426

PubMed ID

  • 21360818

Additional Document Info

start page

  • 424

end page

  • 7

volume

  • 6

number

  • 3