Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients Academic Article uri icon

Overview

MeSH Major

  • ATP-Binding Cassette Transporters
  • Antineoplastic Agents
  • Carcinoma, Non-Small-Cell Lung
  • Diarrhea
  • Lung Neoplasms
  • Neoplasm Proteins
  • Quinazolines

abstract

  • The ABCG2 -15622C/T polymorphism and ABCG2 (1143C/T, -15622C/T) haplotype resulted in a gefitinib-dependent, moderate-to-severe diarrhea suggesting that these pharmacogenetic markers should be considered to optimize NSCLC treatment.

publication date

  • February 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.2217/pgs.10.172

PubMed ID

  • 21332310

Additional Document Info

start page

  • 159

end page

  • 70

volume

  • 12

number

  • 2