The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes - Implications for osteoarthritis Academic Article uri icon

Overview

MeSH Major

  • Chondrocytes
  • Epigenesis, Genetic
  • Glucosamine
  • NF-kappa B
  • Nitriles
  • Osteoarthritis
  • Sulfones

abstract

  • We demonstrate for the first time that GlcN and BAY can prevent cytokine-induced demethylation of a specific CpG site in the IL1β promoter and this was associated with decreased expression of IL1β. These studies provide a potential mechanism of action for OA disease modifying agents via NF-kB and, critically, demonstrate the need for further studies to elucidate the role that NF-kB may play in DNA demethylation in human chondrocytes.

publication date

  • February 18, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3937866

Digital Object Identifier (DOI)

  • 10.1016/j.bbrc.2011.01.007

PubMed ID

  • 21219853

Additional Document Info

start page

  • 362

end page

  • 7

volume

  • 405

number

  • 3