Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD56
  • Heart Ventricles
  • Hypertension
  • Polymorphism, Single Nucleotide

abstract

  • This GWAS conducted in hypertensive families identified a variant in NCAM1 associated with LV wall thickness and RWT. NCAM is upregulated during the remodeling period of hypertrophy to heart failure in Dahl salt-sensitive rats. Our initial screening in hypertensive blacks may have provided the context for this novel locus.

publication date

  • February 4, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3328104

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.110.239210

PubMed ID

  • 21212386

Additional Document Info

start page

  • 279

end page

  • 83

volume

  • 108

number

  • 3