Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families
Polymorphism, Single Nucleotide
This GWAS conducted in hypertensive families identified a variant in NCAM1 associated with LV wall thickness and RWT. NCAM is upregulated during the remodeling period of hypertrophy to heart failure in Dahl salt-sensitive rats. Our initial screening in hypertensive blacks may have provided the context for this novel locus.