Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic β-cell death and accelerates the onset of diabetes Academic Article uri icon

Overview

MeSH Major

  • Diabetes Mellitus, Experimental
  • Hepatocyte Growth Factor
  • Insulin-Secreting Cells
  • Proto-Oncogene Proteins c-met

abstract

  • These results show that HGF/c-Met is critical for β-cell survival by attenuating NF-κB signaling and suggest that activation of the HGF/c-Met signaling pathway represents a novel strategy for enhancing β-cell protection.

publication date

  • February 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3028352

Digital Object Identifier (DOI)

  • 10.2337/db09-1305

PubMed ID

  • 20980460

Additional Document Info

start page

  • 525

end page

  • 36

volume

  • 60

number

  • 2