Immune modulation in heart failure: Past challenges and future hopes Review uri icon

Overview

MeSH Major

  • Anti-Inflammatory Agents
  • Heart Failure
  • Immunologic Factors
  • Inflammation

abstract

  • Immune-modulation therapy has had great success in various inflammatory diseases. Despite the promising results of preliminary studies in anti-tumor necrosis factor-α therapies, large randomized studies have lacked positive clinical outcomes in patients with heart failure. These results have led to the idea that therapies directed toward specific inflammatory mediators may not be the answer and lead us toward the development of novel anti-inflammatory strategies that may involve a broader spectrum of inflammatory mediators. Therapeutic plasma exchange has been demonstrated as a safe treatment, and preliminary outcomes led us to develop new treatment schemes.

publication date

  • March 2011

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s11897-010-0044-2

PubMed ID

  • 21221862

Additional Document Info

start page

  • 28

end page

  • 37

volume

  • 8

number

  • 1