Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling
ATP-Binding Cassette Transporters
rac GTP-Binding Proteins
Deletion of ABCA1 and ABCG1 causes an increased cholesterol content on the inner leaflet of the PM, associated with increased Rac1 PM localization, activation, and impairment of migration. ABCA1 and ABCG1 facilitate macrophage chemotaxis by promoting PM transbilayer cholesterol movement and may contribute to the ability of HDL to promote regression of atherosclerosis.