Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling Academic Article uri icon

Overview

MeSH Major

  • ATP-Binding Cassette Transporters
  • Cell Movement
  • Lipoproteins
  • Macrophages
  • Neuropeptides
  • Signal Transduction
  • rac GTP-Binding Proteins

abstract

  • Deletion of ABCA1 and ABCG1 causes an increased cholesterol content on the inner leaflet of the PM, associated with increased Rac1 PM localization, activation, and impairment of migration. ABCA1 and ABCG1 facilitate macrophage chemotaxis by promoting PM transbilayer cholesterol movement and may contribute to the ability of HDL to promote regression of atherosclerosis.

publication date

  • January 21, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3097897

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.110.228619

PubMed ID

  • 21148432

Additional Document Info

start page

  • 194

end page

  • 200

volume

  • 108

number

  • 2