One statistical test is sufficient for assessing new predictive markers Academic Article uri icon

Overview

MeSH Major

  • Biomarkers
  • Data Interpretation, Statistical
  • Disease

abstract

  • Evaluation of the statistical significance of a new predictor when there are existing clinical predictors is most appropriately accomplished in the context of a regression model. Although comparison of AUCs is a conceptually equivalent approach to the likelihood ratio and Wald test, it has vastly inferior statistical properties. Use of both approaches will frequently lead to inconsistent conclusions. Nonetheless, comparison of receiver operating characteristic curves remains a useful descriptive tool for initial evaluation of whether a new predictor might be of clinical relevance.

publication date

  • February 2, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3042425

Digital Object Identifier (DOI)

  • 10.1186/1471-2288-11-13

PubMed ID

  • 21276237

Additional Document Info

start page

  • 13

volume

  • 11