Differential regulation of transcription through distinct suppressor of hairless DNA binding site architectures during notch signaling in proneural clusters Academic Article uri icon

Overview

MeSH Major

  • DNA
  • Drosophila Proteins
  • Drosophila melanogaster
  • Receptors, Notch
  • Repressor Proteins

abstract

  • In Drosophila melanogaster, achaete (ac) and m8 are model basic helix-loop-helix activator (bHLH A) and repressor genes, respectively, that have the opposite cell expression pattern in proneural clusters during Notch signaling. Previous studies have shown that activation of m8 transcription in specific cells within proneural clusters by Notch signaling is programmed by a "combinatorial" and "architectural" DNA transcription code containing binding sites for the Su(H) and proneural bHLH A proteins. Here we show the novel result that the ac promoter contains a similar combinatorial code of Su(H) and bHLH A binding sites but contains a different Su(H) site architectural code that does not mediate activation during Notch signaling, thus programming a cell expression pattern opposite that of m8 in proneural clusters.

publication date

  • January 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3019852

Digital Object Identifier (DOI)

  • 10.1128/MCB.00003-10

PubMed ID

  • 21041480

Additional Document Info

start page

  • 22

end page

  • 9

volume

  • 31

number

  • 1