Parvovirus-mediated fetal cardiomyopathy with atrioventricular nodal disease Academic Article uri icon


MeSH Major

  • Atrioventricular Block
  • Cardiomyopathies
  • Parvoviridae Infections
  • Pregnancy Complications, Cardiovascular
  • Pregnancy Complications, Infectious


  • Acute parvovirus B19 infection (API) in pregnancy has been associated with fetal anemia and hydrops fetalis. Direct myocardial damage from API in a fetus and an infant has been described. This report presents a case of fetal second-degree heart block and cardiomyopathy secondary to API. A 19-year-old G4P1112 (gravida 4 para 2 with 1 term delivery, 1 preterm delivery, 1 termination, and 2 living children) was referred at 20 weeks gestation for fetal bradycardia. A 2:1 atrioventricular block was identified by fetal echocardiography at 23 weeks. Hydrops developed at 25 weeks. Amniocentesis and percutaneous umbilical blood sampling demonstrated API. At 31 weeks, the patient presented with preterm labor and delivered a viable female infant, who died of poor cardiac function and arrhythmia on the first day of life. In addition to fetal anemia and hydrops fetalis, API in pregnancy may cause direct fetal myocardial damage and conduction system disease.

publication date

  • January 2011



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1007/s00246-010-9803-9

PubMed ID

  • 20936534

Additional Document Info

start page

  • 84

end page

  • 6


  • 32


  • 1