Reflex testing of resected stage i through III lung adenocarcinomas for EGFR and KRAS mutation: Report on initial experience and clinical utility at a single center Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • DNA Mutational Analysis
  • Genetic Testing
  • Lung Neoplasms
  • Mutation
  • Pneumonectomy
  • Proto-Oncogene Proteins
  • Receptor, Epidermal Growth Factor
  • ras Proteins

abstract

  • The results of the first 3 years of reflex testing at MSKCC reported here demonstrate the feasibility, clinical utility, and potential of this approach. This information allowed for enrollment of patients into clinical trials to explore mutation-specific, directed therapy and led to retrospective studies related to patient outcome. In addition, it may inform selection of chemotherapy for recurrent disease and may help to distinguish multiple primary tumors from metastatic disease.

publication date

  • February 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jtcvs.2010.08.026

PubMed ID

  • 20933246

Additional Document Info

start page

  • 476

end page

  • 80

volume

  • 141

number

  • 2