Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in Met-amplified tumor cells with or without resistance to selective MET inhibition Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • HSP90 Heat-Shock Proteins
  • Heterocyclic Compounds, 4 or More Rings
  • Proto-Oncogene Proteins c-met

abstract

  • Our study provides evidence for the efficacy of HSP-90 inhibition in MET-amplified cancer cells, particularly when MET kinase inhibitor resistance has emerged.

publication date

  • January 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3263825

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-10-0253

PubMed ID

  • 21208906

Additional Document Info

start page

  • 122

end page

  • 33

volume

  • 17

number

  • 1