Mutations in GNA11 in uveal melanoma Academic Article uri icon

Overview

MeSH Major

  • GTP-Binding Protein alpha Subunits
  • Melanoma
  • Mutation
  • Nevus, Blue
  • Uveal Neoplasms

abstract

  • Of the uveal melanomas we analyzed, 83% had somatic mutations in GNAQ or GNA11. Constitutive activation of the pathway involving these two genes appears to be a major contributor to the development of uveal melanoma. (Funded by the National Institutes of Health and others.).

publication date

  • December 2, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3107972

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1000584

PubMed ID

  • 21083380

Additional Document Info

start page

  • 2191

end page

  • 9

volume

  • 363

number

  • 23