Long-term clinical course of dry eye in patients with chronic graft-versus-host disease referred for eye examination
Diagnostic Techniques, Ophthalmological
Dry Eye Syndromes
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Referral and Consultation
Stable visual acuity, tear production, and lissamine green staining and a statistically insignificant improvement in dry eye symptoms were observed in the 9 participants who completed this 3-year prospective case series of 49 patients with cGVHD. Insofar as these patients represent a minority (18%) of the original cohort, their clinical course may not be generalizable to all patients with cGVHD but may still suggest that this patient population's prognosis could be characterized by stability and excellent vision. Sufficiently powered prospective studies are required to validate these postulates.