Specific Functions for ERK/MAPK Signaling during PNS Development Academic Article uri icon

Overview

MeSH Major

  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinase 7
  • Myelin Sheath
  • Neural Crest
  • Oligodendroglia
  • Peripheral Nervous System
  • Schwann Cells
  • Signal Transduction

abstract

  • We have established functions of the stimulus-dependent MAPKs, ERK1/2 and ERK5, in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent, and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted differentiation and marked hypomyelination of axons. The Schwann cell phenotypes are similar to those reported in neuregulin-1 and ErbB mutant mice, and neuregulin effects could not be elicited in glial precursors lacking Erk1/2. ERK/MAPK regulation of myelination was specific to Schwann cells, as deletion in oligodendrocyte precursors did not impair myelin formation, but reduced precursor proliferation. Our data suggest a tight linkage between developmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors.

publication date

  • January 13, 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3060558

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2010.12.003

PubMed ID

  • 21220101

Additional Document Info

start page

  • 91

end page

  • 105

volume

  • 69

number

  • 1