MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease Academic Article uri icon

Overview

MeSH Major

  • Actin Depolymerizing Factors
  • Alzheimer Disease
  • Gene Expression Regulation
  • MicroRNAs

abstract

  • Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD. These results suggest that microRNAs may play an important role in cytoskeletal pathology in AD.

publication date

  • December 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3002958

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0015546

PubMed ID

  • 21179570

Additional Document Info

start page

  • e15546

volume

  • 5

number

  • 12