Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes Academic Article uri icon

Overview

MeSH Major

  • CD8-Positive T-Lymphocytes
  • Herpes Genitalis
  • Herpesvirus 2, Human
  • Immunity, Mucosal
  • Models, Immunological
  • Virus Replication
  • Virus Shedding

abstract

  • Herpes simplex virus-2 (HSV-2) shedding episodes in humans vary markedly in duration and virologic titer within an infected person over time, an observation that is unexplained. To evaluate whether host or virological factors more closely accounted for this variability, we combined measures of viral replication and CD8(+) lymphocyte density in genital biopsies, with a stochastic mathematical model of HSV-2 infection. Model simulations reproduced quantities of virus and duration of shedding detected in 1,003 episodes among 386 persons. In the simulations, local CD8(+) lymphocyte density in the mucosa at episode onset predicted peak HSV DNA copy number and whether genital lesions or subclinical shedding occurred. High density of CD8(+) T cells in the mucosa correlated with decreased infected cell lifespan and fewer infected epithelial cells before episode clearance. If infected cell lifespan increased by 15 min because of CD8(+) lymphocyte decay, then there was potential for a thousandfold increase in the number of infected cells. The model suggests that the rate of containment of infected cells by the peripheral mucosal immune system is the major driver of duration and severity of HSV-2 reactivation in the immunocompetent host.

publication date

  • November 2, 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2973882

Digital Object Identifier (DOI)

  • 10.1073/pnas.1006614107

PubMed ID

  • 20956313

Additional Document Info

start page

  • 18973

end page

  • 8

volume

  • 107

number

  • 44