Cardiomyocyte NF-κB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure Academic Article uri icon

Overview

MeSH Major

  • Heart Failure
  • Myocytes, Cardiac
  • Transcription Factor RelA

abstract

  • persistent myocyte NF-κB p65 activation in HF exacerbates cardiac remodelling by imparting pro-inflammatory, pro-fibrotic, and pro-apoptotic effects. p65 modulation of cell death in HF may occur in part from NF-κB-mediated transformation of the ER stress response from one of adaptation to one of apoptosis.

publication date

  • January 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3002872

Digital Object Identifier (DOI)

  • 10.1093/cvr/cvq274

PubMed ID

  • 20797985

Additional Document Info

start page

  • 129

end page

  • 38

volume

  • 89

number

  • 1