Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure Academic Article uri icon

Overview

MeSH Major

  • Blood Pressure
  • Chromaffin Cells
  • Dopamine beta-Hydroxylase
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Transcription, Genetic

abstract

  • These results suggest that DBH promoter variant C-2073T is functional in vivo: this promoter variant seems to initiate a cascade of transcriptional and biochemical changes including augmented DBH secretion, eventuating in elevation of basal BP, and hence cardiovascular risk. The observations suggest new strategies for probing the pathophysiology, risk, and treatment of hypertension.

publication date

  • January 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4906639

Digital Object Identifier (DOI)

  • 10.1038/ajh.2010.186

PubMed ID

  • 20814407

Additional Document Info

start page

  • 24

end page

  • 32

volume

  • 24

number

  • 1