Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals Academic Article uri icon

Overview

MeSH Major

  • Aldehyde Reductase
  • Smoking

abstract

  • Smoking per se mediates upregulation of AKR1B10 expression in the airway epithelia of healthy smokers with no evidence of lung cancer. In the context of these observations and the link of AKR1B10 to the metabolism of retinals and to lung cancer, the smoking-induced upregulation of AKR1B10 may be an early process in the multiple events leading to lung cancer.

publication date

  • December 2010

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2998206

Digital Object Identifier (DOI)

  • 10.1378/chest.09-2634

PubMed ID

  • 20705797

Additional Document Info

start page

  • 1402

end page

  • 10

volume

  • 138

number

  • 6