Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement Academic Article uri icon


MeSH Major

  • Cell Transformation, Neoplastic
  • Gene Rearrangement
  • Genes, myc
  • Lymphoma, Follicular
  • Lymphoma, Large-Cell, Immunoblastic
  • Plasma Cells


  • Follicular lymphoma (FL) is an indolent lymphoma that transforms to high-grade lymphoma, mostly diffuse large B-cell lymphoma, in about a third of patients. We present the first report of a case of FL that transformed to plasmablastic lymphoma (PBL). Clonal transformation of the FL to PBL was evidenced by identical IGH/BCL2 gene rearrangements and VDJ gene usage in rearranged IGH genes. IGH/ BCL2 translocation was retained in the PBL, which also acquired c-myc gene rearrangement. Genealogic analysis based on somatic hypermutation of the rearranged IGH genes of both FL and PBL suggests that transformation of the FL to PBL occurred most likely by divergent evolution from a common progenitor cell rather than direct evolution from the FL clone. Our study of this unusual case expands the histologic spectrum of FL transformation and increases our understanding of the pathogenetic mechanisms of transformation of indolent lymphomas to aggressive lymphomas.

publication date

  • December 2010



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1309/AJCPWY1SGJ9IEAOR

PubMed ID

  • 21088162

Additional Document Info

start page

  • 972

end page

  • 81


  • 134


  • 6