Assembling ligands in situ using bioorthogonal boronate ester synthesis. Academic Article uri icon

Overview

MeSH

  • Amino Acid Sequence
  • Dimerization
  • Esters
  • Kinetics
  • Peptides
  • Receptors, Thrombopoietin
  • Salicylamides

MeSH Major

  • Boronic Acids
  • Ligands

abstract

  • Many molecules that could manipulate cellular function are not practical due to their large size and concomitant undesirable pharmocokinetic properties. Here, we describe a bioorthogonal, highly stable boronate ester (HiSBE) synthesis and use this reaction to synthesize a biologically active molecule from smaller precursors in a physiological context. The rapid rate of HiSBE synthesis suggests that it may be useful for assembling a wide variety of biologically active molecules in physiological solutions. Copyright © 2010 Elsevier Ltd. All rights reserved.

publication date

  • November 24, 2010

has subject area

  • Amino Acid Sequence
  • Boronic Acids
  • Dimerization
  • Esters
  • Kinetics
  • Ligands
  • Peptides
  • Receptors, Thrombopoietin
  • Salicylamides

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3149976

Digital Object Identifier (DOI)

  • 10.1016/j.chembiol.2010.09.008

PubMed ID

  • 21095566

Additional Document Info

start page

  • 1171

end page

  • 1176

volume

  • 17

number

  • 11